Cisplatin, Methotrexate & Vinblastine (CMV) Chemotherapy

This section is for patients who will receive CMV chemotherapy. It will explain:

• the treatment plan;
• the most common side effects you may have and ways in which you can reduce or even overcome them when you are at home;
• any serious side effects that may affect your life-style;
• who to contact when you need advice about the chemotherapy.

It will also be helpful for family and friends who may be worried at how the treatment may affect you and ways in which they can help.

Treatment Plan 1
Your treatment is given every 3 weeks for 4 cycles. Each cycle requires two visits to the hospital. On the first visit, you need to stay in hospital overnight. The second visit is given a week later in the day case unit and takes a few minutes. The nurses give the treatment as an infusion (drip) into a vein in the back of your hand or forearm using a plastic needle called a cannula or butterfly.

Side Effects 2
Nausea and Vomiting (feeling sick and being sick)
This may start a few hours to 48 hours after treatment unless you take your anti-emetics (anti-sickness) tablets as prescribed. You can help by eating small, frequent meals and avoiding rich, spicy foods and alcohol for 48 hours after treatment. If sickness lasts longer than this, telephone for advice and let your nurse or doctor know at the next hospital visit. A different anti-emetic may help. Some anti-emetics may cause drowsiness. If affected, it is important you do not drive or operate machinery.

Your Bone Marrow
Chemotherapy affects the bone marrow where blood cells are made and may temporarily lower the three main types of blood cells.

• Your white cells leaving you more prone to infection.
• Your red cells causing anaemia.
• Your platelets which may leave you prone to bruising or bleeding.

Because of this we will require blood tests each time you attend and in between at your nearest hospital. Telephone for advice if:

• your temperature rises above 37.5ºC (100ºF) which may mean an infection. The nurse will show you how to take your own temperature if you do not know;
• you have any bruising or bleeding you cannot account for;
• you feel tired or short of breath, which may mean you are anaemic and need a blood transfusion; or
• you feel generally unwell

Your Kidneys
The chemotherapy can affect your kidneys that produce urine (water, wee). We will give you plenty of fluids through the drip to help prevent this and will keep a careful check on your kidney function through blood tests each time you attend for treatment. If your kidneys are affected, the doctor may decide to change you to a different type of chemotherapy.

Your Bowels
You may experience diarrhoea (loose bowels / stools) in the first 24-hours. If it lasts longer than this, your GP or pharmacist can advise you.

Your Mouth
Your mouth is prone to ulcers and infection so clean your teeth & gums after each meal. Avoid mouthwashes containing alcohol, because they increase dryness in your mouth. Salt water is good (1 tsp. salt to 1 pint boiled, cooled water). If your mouth continues to be very sore or becomes ulcerated, telephone for advice.
You may also find that you get a metallic taste in your mouth. You can help yourself by sucking on strong flavoured sweets.

Your Fertility
We advise you not to become pregnant or father a child during chemotherapy and for 2 months after the last treatment because the drugs may harm the developing baby. So, before starting treatment discuss methods of contraception with your partner and, if necessary, a nurse or doctor. The treatment may also affect your ability to become pregnant in the future.

Your Fingers and Toes
As treatment progresses, you may experience pins & needles in your fingers and toes. Although harmless, let the doctor know at your next visit, he/she may want to reduce or change the drug. In the meantime be cautious with hot water and appliances. The sensation can take up to 12 months to settle.

Tiredness
You may feel very tired at times. It is important that you do as much or as little as you feel like doing. You may need to take time off work.

Your Hair
The treatment does not usually cause complete hair loss although you may find your hair becomes thinner or more brittle. If you do experience hair loss, the nurse can arrange a wig for you. However, hair loss or hair thinning is temporary and your hair will return when your treatment is complete.

Your Hearing
Sometimes the chemotherapy can affect your hearing. If you notice any deafness, ringing or buzzing in your ears, let the nurse or doctor know at your next visit.

It is hard to say which side effects will affect you and to what extent. Be guided by how you feel each day.

Who to Contact:
Sulby Ward 0151 604 7459 at all other times

References:
1. CCO 1999. Chemotherapy Protocols. Clatterbridge Centre for Oncology.
2. Cytotoxic Chemotherapy. 5th ed. Eli Lilly Oncology.

Further Reading:
CCO Patient Information Series:

• Chemotherapy (No.8)
• Sex and Chemotherapy (No.10)
• Hair Care Advice (No. 8D)
  

CancerBACUP leaflets.

• Chemotherapy
• Sexuality and Cancer
• Coping with Hair Loss
  

Other Sources of Information:
Cancer Information Centre
Clatterbridge Centre for Oncology,
Bebington, Wirral CH63 4JY
Tel: 0151 482 7722.
www.ccotrust.co.uk

BACUP
3 Bath Place
Rivington St
London EC2A 3JR Tel.0800 181199
www.cancerbacup.org.uk

Taxol

Taxol & Cisplatin

Taxol & Carboplatin

CAE

Adriamycin

BMC

Carboplatin

5FU & Folinic Acid

AC

CAV

Cisplatin

CMF

CMV

Epirubicin

Irinotecan

Mitozantrone